This study aimed to investigate the impact of reducing the number of wearable devices on the ability to assess gait impairments in patients with PD. Comparable performance was observed for predicting MDS-UPDRS gait score with features derived using 1, 3, and 6 wearable devices. Furthermore, predicted MDS-UPDRS gait scores from all 3 models differed significantly between On and Off motor states. Our results suggest a marginal benefit in using multiple devices for assessing gait impairments in patients with PD when compared with gait features derived using a single lumbar-mounted accelerometer.